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What is a nanoparticle? A nanoparticle is a particle having an average size of 1 to 999 nanometers. A nanometer is 10 -9meter. Its abbreviation is nm. How large are the calcite nanoparticles in Tooth Builder® Toothpaste and Squigle® Jr Toothpaste? Tooth Builder's and Squigle Jr's patented nanoparticles are made of calcite (calcium carbonate, CaCO3). Their average size is 70 nm. By comparison, a red blood cell is roughly the shape of a hockey puck, with a diameter of 6-8 microns (60 …